Hair colour: Unterschied zwischen den Versionen
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| Zeile 21: | Zeile 21: | ||
* Asp84Glu (rs1805006) | * Asp84Glu (rs1805006) | ||
* Val92Met (rs2228479) - red | * Val92Met (rs2228479) - red | ||
| + | * Gly104Ser (rs2229617) | ||
* Arg151Cys (rs1805007) - red | * Arg151Cys (rs1805007) - red | ||
| + | * Arg151Gly (rs1805007) | ||
* Y152OCH | * Y152OCH | ||
| − | * | + | * Ile155Thr (rs1110400) |
| + | * Val156Leu (rs3212365) | ||
| + | * Thr157Ile (rs104894524) | ||
| + | * Pro159Thr (rs104894523) | ||
* Arg160Trp (rs1805008) - red | * Arg160Trp (rs1805008) - red | ||
* Arg142His (rs11547464) - red | * Arg142His (rs11547464) - red | ||
| Zeile 30: | Zeile 35: | ||
* Asp294His (rs1805009) - red | * Asp294His (rs1805009) - red | ||
* 537insC | * 537insC | ||
| − | |||
| − | |||
Uncommon variants: | Uncommon variants: | ||
* Arg307Gly - Neanderthal variant | * Arg307Gly - Neanderthal variant | ||
| + | * Phe147Delta | ||
OCA2 gene (chromosome 15q11.2–12) variants: | OCA2 gene (chromosome 15q11.2–12) variants: | ||
| − | * rs1800407 - red | + | * Arg305Trp (rs1800401) |
| − | + | * Arg419Gln (rs1800407) - red | |
* rs16950821 | * rs16950821 | ||
* rs7174027 | * rs7174027 | ||
Version vom 11. April 2012, 16:36 Uhr
Melanin levels (only two of those can be on "high" at once, one from the father and one from the mother):
- Black Eumelanin (white to black)
- Brown Eumelanin (white to yellowish brown)
- Pheomelanin (white to red) - MC1R gene, alleles Arg151Cys, Arg160Trp, Asp294His, Arg142His - also inhibit melanin production in skin, resulting in a paler skin.
Typical combinations:
- Black Eumelanin only -> Black
- Brown Eumelanin only -> Brown
- Pheomelanin only -> Red
- Black Eumelanin & Brown Eumelanin -> Dark Brown
- Black Eumelanin & Pheomelanin -> Chestnut Brown
- Brown Eumelanin & Pheomelanin -> Auburn
- low amount of all -> Blonde
- negligable amount of all -> White
Common MC1R (melanocortin 1 receptor) gene (chromosome 16q24.3) variants:
- N29insA - red
- Val60Leu (rs1805005) - blonde
- Asp84Glu (rs1805006)
- Val92Met (rs2228479) - red
- Gly104Ser (rs2229617)
- Arg151Cys (rs1805007) - red
- Arg151Gly (rs1805007)
- Y152OCH
- Ile155Thr (rs1110400)
- Val156Leu (rs3212365)
- Thr157Ile (rs104894524)
- Pro159Thr (rs104894523)
- Arg160Trp (rs1805008) - red
- Arg142His (rs11547464) - red
- Arg163Gln (rs885479) - blonde
- His260Pro
- Asp294His (rs1805009) - red
- 537insC
Uncommon variants:
- Arg307Gly - Neanderthal variant
- Phe147Delta
OCA2 gene (chromosome 15q11.2–12) variants:
- Arg305Trp (rs1800401)
- Arg419Gln (rs1800407) - red
- rs16950821
- rs7174027
- rs4778138 - brown
- rs4778241
- rs7495174
ASIP (agouti signaling protein) gene variants:
- rs1015362 - blonde-red
- rs6058017
- rs2378249
HERC2 (hect domain and RLD 2) gene variants:
- rs12913832 - black
- rs7183877
- rs11635884
- rs916977 - red
- rs8039195 - red
SLC45A2 gene variants:
- rs16891982 - black
- rs28777 - black
- rs26722 - black
IRF4 gene variants:
- rs12203592 - black
- rs9378805
EXOC2 gene variants:
- rs4959270 - black
TYRP1 gene (chromosome 9p23) variants:
- rs1408799
- rs2733832
- rs683
TYRP2 gene (chromosome 13q31–32) variants:
TPCN2 gene variants:
- rs35264875
- rs3829241
- rs2305498
- rs1011176
TYR gene (chromosome 11q14–21) variants:
- Ser192Tyr (rs1042602)
- Tyr192Ser - albino?
- Arg402Gln (rs1126809) - albino?
- rs1393350 - brown
KITLG gene variants:
- rs12821256
SLC24A4 gene variants:
- rs12896399
- rs4904868 - blonde
- rs2402130 - dark blonde
