Hair colour: Unterschied zwischen den Versionen
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Common MC1R (melanocortin 1 receptor) gene (chromosome 16q24.3) variants: | Common MC1R (melanocortin 1 receptor) gene (chromosome 16q24.3) variants: | ||
| + | * N29insA - red | ||
| + | * Val60Leu (rs1805005) - blonde | ||
| + | * Asp84Glu (rs1805006) | ||
| + | * Val92Met (rs2228479) - red | ||
* Arg151Cys (rs1805007) - red | * Arg151Cys (rs1805007) - red | ||
| + | * Y152OCH | ||
| + | * IIe155Thr (rs1110400) | ||
* Arg160Trp (rs1805008) - red | * Arg160Trp (rs1805008) - red | ||
| − | |||
* Arg142His (rs11547464) - red | * Arg142His (rs11547464) - red | ||
| − | |||
| − | |||
* Arg163Gln (rs885479) - blonde | * Arg163Gln (rs885479) - blonde | ||
* His260Pro | * His260Pro | ||
| − | * | + | * Asp294His (rs1805009) - red |
* 537insC | * 537insC | ||
| − | |||
* rs8045560 | * rs8045560 | ||
* rs3212346 | * rs3212346 | ||
| − | |||
| − | |||
Uncommon variants: | Uncommon variants: | ||
* Arg307Gly - Neanderthal variant | * Arg307Gly - Neanderthal variant | ||
| − | OCA2 gene variants: | + | OCA2 gene (chromosome 15q11.2–12) variants: |
* rs1800407 - red | * rs1800407 - red | ||
* rs1800401 | * rs1800401 | ||
| Zeile 68: | Zeile 68: | ||
* rs4959270 - black | * rs4959270 - black | ||
| − | TYRP1 gene variants: | + | TYRP1 gene (chromosome 9p23) variants: |
* rs1408799 | * rs1408799 | ||
* rs2733832 | * rs2733832 | ||
* rs683 | * rs683 | ||
| + | |||
| + | TYRP2 gene (chromosome 13q31–32) variants: | ||
TPCN2 gene variants: | TPCN2 gene variants: | ||
| Zeile 79: | Zeile 81: | ||
* rs1011176 | * rs1011176 | ||
| − | TYR gene variants: | + | TYR gene (chromosome 11q14–21) variants: |
| − | * rs1042602 | + | * Ser192Tyr (rs1042602) |
| + | * Tyr192Ser - albino? | ||
| + | * Arg402Gln (rs1126809) - albino? | ||
* rs1393350 - brown | * rs1393350 - brown | ||
Version vom 11. April 2012, 15:46 Uhr
Melanin levels (only two of those can be on "high" at once, one from the father and one from the mother):
- Black Eumelanin (white to black)
- Brown Eumelanin (white to yellowish brown)
- Pheomelanin (white to red) - MC1R gene, alleles Arg151Cys, Arg160Trp, Asp294His, Arg142His - also inhibit melanin production in skin, resulting in a paler skin.
Typical combinations:
- Black Eumelanin only -> Black
- Brown Eumelanin only -> Brown
- Pheomelanin only -> Red
- Black Eumelanin & Brown Eumelanin -> Dark Brown
- Black Eumelanin & Pheomelanin -> Chestnut Brown
- Brown Eumelanin & Pheomelanin -> Auburn
- low amount of all -> Blonde
- negligable amount of all -> White
Common MC1R (melanocortin 1 receptor) gene (chromosome 16q24.3) variants:
- N29insA - red
- Val60Leu (rs1805005) - blonde
- Asp84Glu (rs1805006)
- Val92Met (rs2228479) - red
- Arg151Cys (rs1805007) - red
- Y152OCH
- IIe155Thr (rs1110400)
- Arg160Trp (rs1805008) - red
- Arg142His (rs11547464) - red
- Arg163Gln (rs885479) - blonde
- His260Pro
- Asp294His (rs1805009) - red
- 537insC
- rs8045560
- rs3212346
Uncommon variants:
- Arg307Gly - Neanderthal variant
OCA2 gene (chromosome 15q11.2–12) variants:
- rs1800407 - red
- rs1800401
- rs16950821
- rs7174027
- rs4778138 - brown
- rs4778241
- rs7495174
ASIP (agouti signaling protein) gene variants:
- rs1015362 - blonde-red
- rs6058017
- rs2378249
HERC2 (hect domain and RLD 2) gene variants:
- rs12913832 - black
- rs7183877
- rs11635884
- rs916977 - red
- rs8039195 - red
SLC45A2 gene variants:
- rs16891982 - black
- rs28777 - black
- rs26722 - black
IRF4 gene variants:
- rs12203592 - black
- rs9378805
EXOC2 gene variants:
- rs4959270 - black
TYRP1 gene (chromosome 9p23) variants:
- rs1408799
- rs2733832
- rs683
TYRP2 gene (chromosome 13q31–32) variants:
TPCN2 gene variants:
- rs35264875
- rs3829241
- rs2305498
- rs1011176
TYR gene (chromosome 11q14–21) variants:
- Ser192Tyr (rs1042602)
- Tyr192Ser - albino?
- Arg402Gln (rs1126809) - albino?
- rs1393350 - brown
KITLG gene variants:
- rs12821256
SLC24A4 gene variants:
- rs12896399
- rs4904868 - blonde
- rs2402130 - dark blonde
